Impact of Mutations at Arg220 and Thr237 in PER-2 β-Lactamase on Conformation, Activity, and Susceptibility to Inhibitors

PER-2 accounts for up to 10% of oxyimino-cephalosporin resistance in Klebsiella pneumoniae and Escherichia coli in Argentina and hydrolyzes both cefotaxime and ceftazidime with high catalytic efficiencies (k(cat)/K(m)). Through crystallographic analyses, we recently proposed the existence of a hydro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ruggiero, Melina, Curto, Lucrecia, Brunetti, Florencia, Sauvage, Eric, Galleni, Moreno, Power, Pablo, Gutkind, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444140/
https://ncbi.nlm.nih.gov/pubmed/28320728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02193-16
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados