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Impact of Mutations at Arg220 and Thr237 in PER-2 β-Lactamase on Conformation, Activity, and Susceptibility to Inhibitors
PER-2 accounts for up to 10% of oxyimino-cephalosporin resistance in Klebsiella pneumoniae and Escherichia coli in Argentina and hydrolyzes both cefotaxime and ceftazidime with high catalytic efficiencies (k(cat)/K(m)). Through crystallographic analyses, we recently proposed the existence of a hydro...
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| Pubblicato in: | Antimicrob Agents Chemother |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5444140/ https://ncbi.nlm.nih.gov/pubmed/28320728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02193-16 |
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