Impact of Mutations at Arg220 and Thr237 in PER-2 β-Lactamase on Conformation, Activity, and Susceptibility to Inhibitors

PER-2 accounts for up to 10% of oxyimino-cephalosporin resistance in Klebsiella pneumoniae and Escherichia coli in Argentina and hydrolyzes both cefotaxime and ceftazidime with high catalytic efficiencies (k(cat)/K(m)). Through crystallographic analyses, we recently proposed the existence of a hydro...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Ruggiero, Melina, Curto, Lucrecia, Brunetti, Florencia, Sauvage, Eric, Galleni, Moreno, Power, Pablo, Gutkind, Gabriel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444140/
https://ncbi.nlm.nih.gov/pubmed/28320728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02193-16
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