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Structural basis of the inhibition of class A β-lactamases and penicillin-binding proteins by 6-β-iodopenicillanate
6-β-Halogenopenicillanates are powerful irreversible inhibitors of various β-lactamases and penicillin binding proteins. Upon acylation of these enzymes, the inhibitors are thought to undergo a structural rearrangement associated with the departure of the iodide and formation of a dihydrothiazine ri...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896319/ https://ncbi.nlm.nih.gov/pubmed/19919161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9051526 |
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