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Structural basis of the inhibition of class A β-lactamases and penicillin-binding proteins by 6-β-iodopenicillanate
6-β-Halogenopenicillanates are powerful irreversible inhibitors of various β-lactamases and penicillin binding proteins. Upon acylation of these enzymes, the inhibitors are thought to undergo a structural rearrangement associated with the departure of the iodide and formation of a dihydrothiazine ri...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896319/ https://ncbi.nlm.nih.gov/pubmed/19919161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9051526 |
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