Obesity‐dependent dysregulation of glucose homeostasis in kinase suppressor of ras 2(−/−) mice

Disruption of KSR2 in humans and mice decreases metabolic rate and induces obesity, coincident with dysregulation of glucose homeostasis. Relative to wild‐type mice, ksr2(−/−) mice are small prior to weaning with normal glucose tolerance at 6 weeks of age, but demonstrate excess adiposity by 9 weeks...

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Bibliographic Details
Main Authors: Henry, MaLinda D., Costanzo‐Garvey, Diane L., Klutho, Paula J., Lewis, Robert E.
Format: Artigo
Language:Inglês
Published: Wiley Periodicals, Inc. 2014
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187555/
https://ncbi.nlm.nih.gov/pubmed/24997067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12053
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