Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Myc oncogenic transcription factors (c-Myc, N-Myc, and L-Myc) coordinate the control of cell growth, division, and metabolism. In cancer, Myc overexpression is often associated with aggressive disease, which is in part due to the destruction of select targets by the ubiquitin-proteasome system (eg,...

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Autori principali: Hoellein, Alexander, Fallahi, Mohammad, Schoeffmann, Stephanie, Steidle, Sabine, Schaub, Franz X., Rudelius, Martina, Laitinen, Iina, Nilsson, Lisa, Goga, Andrei, Peschel, Christian, Nilsson, Jonas A., Cleveland, John L., Keller, Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186537/
https://ncbi.nlm.nih.gov/pubmed/25143484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-584524
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