Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

Myc oncoproteins promote continuous cell growth, in part by controlling the transcription of key cell cycle regulators. Here, we report that c-Myc regulates the expression of Aurora A and B kinases (Aurka and Aurkb), and that Aurka and Aurkb transcripts and protein levels are highly elevated in Myc-...

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Detalhes bibliográficos
Main Authors: den Hollander, Jürgen, Rimpi, Sara, Doherty, Joanne R., Rudelius, Martina, Buck, Andreas, Hoellein, Alexander, Kremer, Marcus, Graf, Nikolas, Scheerer, Markus, Hall, Mark A., Goga, Andrei, von Bubnoff, Nikolas, Duyster, Justus, Peschel, Christian, Cleveland, John L., Nilsson, Jonas A., Keller, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938839/
https://ncbi.nlm.nih.gov/pubmed/20519624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-251074
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