Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

Myc oncoproteins promote continuous cell growth, in part by controlling the transcription of key cell cycle regulators. Here, we report that c-Myc regulates the expression of Aurora A and B kinases (Aurka and Aurkb), and that Aurka and Aurkb transcripts and protein levels are highly elevated in Myc-...

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Hauptverfasser: den Hollander, Jürgen, Rimpi, Sara, Doherty, Joanne R., Rudelius, Martina, Buck, Andreas, Hoellein, Alexander, Kremer, Marcus, Graf, Nikolas, Scheerer, Markus, Hall, Mark A., Goga, Andrei, von Bubnoff, Nikolas, Duyster, Justus, Peschel, Christian, Cleveland, John L., Nilsson, Jonas A., Keller, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938839/
https://ncbi.nlm.nih.gov/pubmed/20519624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-251074
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