Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Myc oncogenic transcription factors (c-Myc, N-Myc, and L-Myc) coordinate the control of cell growth, division, and metabolism. In cancer, Myc overexpression is often associated with aggressive disease, which is in part due to the destruction of select targets by the ubiquitin-proteasome system (eg,...

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Bibliographische Detailangaben
Hauptverfasser: Hoellein, Alexander, Fallahi, Mohammad, Schoeffmann, Stephanie, Steidle, Sabine, Schaub, Franz X., Rudelius, Martina, Laitinen, Iina, Nilsson, Lisa, Goga, Andrei, Peschel, Christian, Nilsson, Jonas A., Cleveland, John L., Keller, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186537/
https://ncbi.nlm.nih.gov/pubmed/25143484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-584524
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