Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

The immunosuppressive ligand FK506 and the FK506-binding protein FKBP52 are stimulatory to glucocorticoid receptor (GR) activity. Here, we explore the underlying mechanism by comparing GR activity and phosphorylation status in response to FK506 and the novel nonimmunosuppressive ligand timcodar (VX-...

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Bibliografiske detaljer
Main Authors: Hinds, Terry D, Stechschulte, Lance A, Elkhairi, Fadel, Sanchez, Edwin R
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186452/
https://ncbi.nlm.nih.gov/pubmed/25505617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.76
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