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Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis

Nutrient overload and genetic factors have led to a worldwide epidemic of obesity that is the underlying cause of diabetes, atherosclerosis, and cardiovascular disease. In this study, we used macrolide drugs such as FK506, rapamycin, and macrolide derived, timcodar (VX-853), to determine their effec...

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Détails bibliographiques
Publié dans:PPAR Res
Auteurs principaux: Hinds, Terry D., John, Kezia, McBeth, Lucien, Trabbic, Christopher J., Sanchez, Edwin R.
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848453/
https://ncbi.nlm.nih.gov/pubmed/27190501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6218637
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