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Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis

Nutrient overload and genetic factors have led to a worldwide epidemic of obesity that is the underlying cause of diabetes, atherosclerosis, and cardiovascular disease. In this study, we used macrolide drugs such as FK506, rapamycin, and macrolide derived, timcodar (VX-853), to determine their effec...

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Publicat a:PPAR Res
Autors principals: Hinds, Terry D., John, Kezia, McBeth, Lucien, Trabbic, Christopher J., Sanchez, Edwin R.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848453/
https://ncbi.nlm.nih.gov/pubmed/27190501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6218637
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