FKBP51 Controls Cellular Adipogenesis through p38 Kinase-Mediated Phosphorylation of GRα and PPARγ

Glucocorticoid receptor-α (GRα) and peroxisome proliferator–activated receptor-γ (PPARγ) are critical regulators of adipogenic responses. We have shown that FK506-binding protein 51 (FKBP51) represses the Akt-p38 kinase pathway to reciprocally inhibit GRα but stimulate PPARγ by targeting serine 112...

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Autors principals: Stechschulte, Lance A., Hinds, Terry D., Khuder, Saja S., Shou, Weinian, Najjar, Sonia M., Sanchez, Edwin R.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116587/
https://ncbi.nlm.nih.gov/pubmed/24933247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1022
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