FKBP51 Reciprocally Regulates GRα and PPARγ Activation via the Akt-p38 Pathway

FK506-binding protein 51 (FKBP51) is a negative regulator of glucocorticoid receptor-α (GRα), although the mechanism is unknown. We show here that FKBP51 is also a chaperone to peroxisome proliferator–activated receptor-γ (PPARγ), which is essential for activity, and uncover the mechanism underlying...

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Detalhes bibliográficos
Main Authors: Stechschulte, Lance A., Hinds, Terry D., Ghanem, Simona S., Shou, Weinian, Najjar, Sonia M., Sanchez, Edwin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116593/
https://ncbi.nlm.nih.gov/pubmed/24933248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1023
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