Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

The immunosuppressive ligand FK506 and the FK506-binding protein FKBP52 are stimulatory to glucocorticoid receptor (GR) activity. Here, we explore the underlying mechanism by comparing GR activity and phosphorylation status in response to FK506 and the novel nonimmunosuppressive ligand timcodar (VX-...

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Detalhes bibliográficos
Main Authors: Hinds, Terry D, Stechschulte, Lance A, Elkhairi, Fadel, Sanchez, Edwin R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186452/
https://ncbi.nlm.nih.gov/pubmed/25505617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.76
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