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P16.01 MAGNETIC RESONANCE SPECTROSCOPY AT 3 T FOR IN VIVO DETECTION OF 2-HYDROXYGLUTARATE IN LOWER GRADE GLIOMAS
Isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations are detected in up to 75% grade II-III (lower grade) gliomas. IDH1/2 mutations result in the neomorphic synthesis of the oncometabolite 2-hydroxyglutarate (2HG). The detection of 2HG could help for a non-invasive diagnosis, the clinical follow-up,...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4185658/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou174.298 |
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