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P16.01 MAGNETIC RESONANCE SPECTROSCOPY AT 3 T FOR IN VIVO DETECTION OF 2-HYDROXYGLUTARATE IN LOWER GRADE GLIOMAS
Isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations are detected in up to 75% grade II-III (lower grade) gliomas. IDH1/2 mutations result in the neomorphic synthesis of the oncometabolite 2-hydroxyglutarate (2HG). The detection of 2HG could help for a non-invasive diagnosis, the clinical follow-up,...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4185658/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou174.298 |
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