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BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork
The tumor suppressor protein BRCA1 promotes homologous recombination (HR), a high fidelity mechanism to repair DNA double-strand breaks (DSBs) that arise during normal replication and in response to DNA damaging agents. Recent genetic experiments indicate that BRCA1 also performs an HR-independent f...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4185004/ https://ncbi.nlm.nih.gov/pubmed/25219499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.012 |
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