Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Type II CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated) systems use an RNA-guided DNA endonuclease, Cas9, to generate double-strand breaks in invasive DNA during an adaptive bacterial immune response. Cas9 has been harnessed as a powerful tool for genome ed...

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Hlavní autoři: Jinek, Martin, Jiang, Fuguo, Taylor, David W., Sternberg, Samuel H., Kaya, Emine, Ma, Enbo, Anders, Carolin, Hauer, Michael, Zhou, Kaihong, Lin, Steven, Kaplan, Matias, Iavarone, Anthony T., Charpentier, Emmanuelle, Nogales, Eva, Doudna, Jennifer A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184034/
https://ncbi.nlm.nih.gov/pubmed/24505130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1247997
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