CLEC-2 expression is maintained on activated platelets and on platelet microparticles

The C-type lectin-like receptor CLEC-2 mediates platelet activation through a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 initiates a Src- and Syk-dependent signaling cascade that is closely related to that of the 2 platelet ITAM receptors: glycoprotein (GP)VI and FcγRIIa. A...

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Detalhes bibliográficos
Main Authors: Gitz, Eelo, Pollitt, Alice Y., Gitz-Francois, Jerney J., Alshehri, Osama, Mori, Jun, Montague, Samantha, Nash, Gerard B., Douglas, Michael R., Gardiner, Elizabeth E., Andrews, Robert K., Buckley, Christopher D., Harrison, Paul, Watson, Steve P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183985/
https://ncbi.nlm.nih.gov/pubmed/25150298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-572818
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