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Subdomain II of α-Isopropylmalate Synthase Is Essential for Activity: INFERRING A MECHANISM OF FEEDBACK INHIBITION
The committed step of leucine biosynthesis, converting acetyl-CoA and α-ketoisovalerate into α-isopropylmalate, is catalyzed by α-isopropylmalate synthase (IPMS), an allosteric enzyme subjected to feedback inhibition by the end product l-leucine. We characterized the short form IPMS from Leptospira...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2014
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183828/ https://ncbi.nlm.nih.gov/pubmed/25128527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559716 |
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