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Two Origins for the Gene Encoding α-Isopropylmalate Synthase in Fungi

BACKGROUND: The biosynthesis of leucine is a biochemical pathway common to prokaryotes, plants and fungi, but absent from humans and animals. The pathway is a proposed target for antimicrobial therapy. METHODOLOGY/PRINCIPAL FINDINGS: Here we identified the leuA gene encoding α-isopropylmalate syntha...

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Autori principali: Larson, Erica M., Idnurm, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904702/
https://ncbi.nlm.nih.gov/pubmed/20657649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011605
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