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Structural Basis for l-Lysine Feedback Inhibition of Homocitrate Synthase
The α-aminoadipate pathway of lysine biosynthesis is modulated at the transcriptional and biochemical levels by feedback inhibition. The first enzyme in the α-aminoadipate pathway, homocitrate synthase (HCS), is the target of the feedback regulation and is strongly inhibited by l-lysine. Here we rep...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856251/ https://ncbi.nlm.nih.gov/pubmed/20089861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094383 |
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