Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer: ROLE OF SPECIFICITY PROTEIN (Sp) TRANSCRIPTION FACTORS

The antidiabetic drug metformin exhibits both chemopreventive and chemotherapeutic activity for multiple cancers including pancreatic cancer; however, the underlying mechanism of action of metformin is unclear. A recent study showed that metformin down-regulated specificity protein (Sp) transcriptio...

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Main Authors: Nair, Vijayalekshmi, Sreevalsan, Sandeep, Basha, Riyaz, Abdelrahim, Maen, Abudayyeh, Ala, Rodrigues Hoffman, Aline, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183806/
https://ncbi.nlm.nih.gov/pubmed/25143389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592576
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