Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage

The clustered regularly interspaced short palindromic repeat (CRISPR)-associated enzyme Cas9 is an RNA-guided nuclease that has been widely adapted for genome editing in eukaryotic cells. However, the in vivo target specificity of Cas9 is poorly understood and most studies rely on in silico predicti...

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Bibliografische gegevens
Hoofdauteurs: Cencic, Regina, Miura, Hisashi, Malina, Abba, Robert, Francis, Ethier, Sylvain, Schmeing, T. Martin, Dostie, Josée, Pelletier, Jerry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183563/
https://ncbi.nlm.nih.gov/pubmed/25275497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109213
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