Polyglutamine-expanded androgen receptor interferes with TFEB to elicit pathological autophagy defects in SBMA

Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise, when dysregulated. Here we considered X-linked spinal and bulbar muscular atrophy (SBMA), a repeat disorder caused by polyglutamine-expanded androgen rec...

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Detalhes bibliográficos
Main Authors: Cortes, Constanza J., Miranda, Helen C., Frankowski, Harald, Batlevi, Yakup, Young, Jessica E., Le, Amy, Ivanov, Nishi, Sopher, Bryce L., Carromeu, Cassiano, Muotri, Alysson R., Garden, Gwenn A., La Spada, Albert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180729/
https://ncbi.nlm.nih.gov/pubmed/25108912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3787
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