Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis

Proteolysis of polyglutamine-expanded proteins is thought to be a required step in the pathogenesis of several neurodegenerative diseases. The accepted view for many polyglutamine proteins is that proteolysis of the mutant protein produces a “toxic fragment” that induces neuronal dysfunction and dea...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Heine, Erin M., Berger, Tamar R., Pluciennik, Anna, Orr, Christopher R., Zboray, Lori, Merry, Diane E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432278/
https://ncbi.nlm.nih.gov/pubmed/25795778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617894
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