Polyglutamine-Expanded Androgen Receptor Truncation Fragments Activate a Bax-Dependent Apoptotic Cascade Mediated by DP5/Hrk

Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by a polyglutamine (polyQ) repeat expansion in the androgen receptor (AR). PolyQ-AR neurotoxicity may involve generation of an N-terminal truncation fragment, as such peptides occur in SBMA patients and mouse mod...

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Main Authors: Young, Jessica E., Garden, Gwenn A., Martinez, Refugio A., Tanaka, Fumiaki, Miguel Sandoval, C., Smith, Annette C., Sopher, Bryce L., Lin, Amy, Fischbeck, Kenneth H., Ellerby, Lisa M., Morrison, Richard S., Taylor, J. Paul, La Spada, Albert R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746676/
https://ncbi.nlm.nih.gov/pubmed/19228953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4072-08.2009
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