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Inefficient degradation of truncated polyglutamine proteins by the proteasome
Accumulation of mutant proteins into misfolded species and aggregates is characteristic for diverse neurodegenerative diseases including the polyglutamine diseases. While several studies have suggested that polyglutamine protein aggregates impair the ubiquitin–proteasome system, the molecular mechan...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524390/ https://ncbi.nlm.nih.gov/pubmed/15470501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600426 |
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