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Inefficient degradation of truncated polyglutamine proteins by the proteasome

Accumulation of mutant proteins into misfolded species and aggregates is characteristic for diverse neurodegenerative diseases including the polyglutamine diseases. While several studies have suggested that polyglutamine protein aggregates impair the ubiquitin–proteasome system, the molecular mechan...

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Detalhes bibliográficos
Main Authors: Holmberg, Carina I, Staniszewski, Kristine E, Mensah, Kwame N, Matouschek, Andreas, Morimoto, Richard I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524390/
https://ncbi.nlm.nih.gov/pubmed/15470501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600426
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