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Substrate selection by the proteasome during degradation of protein complexes

The proteasome controls the turnover of most cellular proteins. Two structural features are typically required for proteins to be degraded: covalently attached ubiquitin polypeptides that allow binding to the proteasome, and an unstructured region in the targeted protein that initiates proteolysis....

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Autori principali: Prakash, Sumit, Inobe, Tomonao, Hatch, Ace Joseph, Matouschek, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670781/
https://ncbi.nlm.nih.gov/pubmed/19029916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.130
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