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Substrate selection by the proteasome during degradation of protein complexes
The proteasome controls the turnover of most cellular proteins. Two structural features are typically required for proteins to be degraded: covalently attached ubiquitin polypeptides that allow binding to the proteasome, and an unstructured region in the targeted protein that initiates proteolysis....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670781/ https://ncbi.nlm.nih.gov/pubmed/19029916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.130 |
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