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Sumo E2 Ligase UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes

RATIONALE: Impairment of proteasomal function is pathogenic in a number of cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates. The ubiquitin proteasome system (UPS) is primarily responsible for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gupta, Manish K., Gulick, James, Liu, Ruijie, Wang, Xuejun, Molkentin, Jeffery D., Robbins, Jeffrey
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180728/
https://ncbi.nlm.nih.gov/pubmed/25097219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.304760
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