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Sumo E2 Ligase UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes

RATIONALE: Impairment of proteasomal function is pathogenic in a number of cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates. The ubiquitin proteasome system (UPS) is primarily responsible for...

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Autori principali: Gupta, Manish K., Gulick, James, Liu, Ruijie, Wang, Xuejun, Molkentin, Jeffery D., Robbins, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180728/
https://ncbi.nlm.nih.gov/pubmed/25097219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.304760
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