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Sumo E2 Ligase UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes
RATIONALE: Impairment of proteasomal function is pathogenic in a number of cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates. The ubiquitin proteasome system (UPS) is primarily responsible for...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180728/ https://ncbi.nlm.nih.gov/pubmed/25097219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.304760 |
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