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The COP9 Signalosome Is Required for Autophagy, Proteasome-Mediated Proteolysis, and Cardiomyocyte Survival in Adult Mice

BACKGROUND: The COP9 signalosome (CSN) is an evolutionarily conserved protein complex composed of 8 unique protein subunits (CSN1 through CSN8). We have recently discovered in perinatal mouse hearts that CSN regulates not only proteasome-mediated proteolysis but also macroautophagy. However, the phy...

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Bibliografische gegevens
Hoofdauteurs: Su, Huabo, Li, Jie, Osinska, Hanna, Li, Faqian, Robbins, Jeffrey, Liu, Jinbao, Wei, Ning, Wang, Xuejun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835345/
https://ncbi.nlm.nih.gov/pubmed/23873473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000338
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