Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

The COP9 signalosome (CSN), an evolutionally highly conserved protein complex composed of 8 unique subunits (CSN1 through CSN8) in higher eukaryotes, is purported to modulate protein degradation mediated by the ubiquitin-proteasome system (UPS) but this has not been demonstrated in a critical mitoti...

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Bibliografiske detaljer
Main Authors: Lei, Daoxiong, Li, Faqian, Su, Huabo, Liu, Jinbao, Wei, Ning, Wang, Xuejun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698095/
https://ncbi.nlm.nih.gov/pubmed/23840878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067793
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