Intersubunit conformational changes mediate epithelial sodium channel gating

The epithelial Na(+) channel (ENaC) functions as a pathway for Na(+) absorption in the kidney and lung, where it is crucial for Na(+) homeostasis and blood pressure regulation. However, the basic mechanisms that control ENaC gating are poorly understood. Here we define a role in gating for residues...

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Bibliografiske detaljer
Main Authors: Collier, Daniel M., Tomkovicz, Vivian R., Peterson, Zerubbabel J., Benson, Christopher J., Snyder, Peter M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178938/
https://ncbi.nlm.nih.gov/pubmed/25225551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411208
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