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Identification of Epithelial Na(+) Channel (ENaC) Intersubunit Cl(−) Inhibitory Residues Suggests a Trimeric αγβ Channel Architecture
The extracellular domain of the epithelial Na(+) channel (ENaC) is exposed to a wide range of anion concentrations in the kidney. We have previously demonstrated that extracellular Cl(−) inhibits ENaC activity. To identify sites involved in Cl(−) inhibition, we mutated residues in the extracellular...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057804/ https://ncbi.nlm.nih.gov/pubmed/21149458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198127 |
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