Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

Viral protease inhibitors are remarkably effective at blocking the replication of viruses such as human immunodeficiency virus and hepatitis C virus, but they inevitably lead to the selection of inhibitor-resistant mutants, which may contribute to ongoing disease. Protease inhibitors blocking the re...

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Autori principali: Deng, Xufang, StJohn, Sarah E., Osswald, Heather L., O'Brien, Amornrat, Banach, Bridget S., Sleeman, Katrina, Ghosh, Arun K., Mesecar, Andrew D., Baker, Susan C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178758/
https://ncbi.nlm.nih.gov/pubmed/25100843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01528-14
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