DESC1 and MSPL Activate Influenza A Viruses and Emerging Coronaviruses for Host Cell Entry

The type II transmembrane serine protease (TTSP) TMPRSS2 cleaves and activates the influenza virus and coronavirus surface proteins. Expression of TMPRSS2 is essential for the spread and pathogenesis of H1N1 influenza viruses in mice. In contrast, H3N2 viruses are less dependent on TMPRSS2 for viral...

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Detalhes bibliográficos
Main Authors: Zmora, Pawel, Blazejewska, Paulina, Moldenhauer, Anna-Sophie, Welsch, Kathrin, Nehlmeier, Inga, Wu, Qingyu, Schneider, Heike, Pöhlmann, Stefan, Bertram, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178745/
https://ncbi.nlm.nih.gov/pubmed/25122802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01427-14
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