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Functional Analysis and purification of a Pen-2 Fusion Protein for γ-Secretase Structural Studies
The 19-transmembrane, multi-subunit γ-secretase complex generates the amyloid β-peptide (Aβ) of Alzheimer's disease (AD) by an unusual intramembrane proteolysis of the β-amyloid precursor protein (APP). The complex, which similarly processes many other type 1 transmembrane substrates, is compos...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4177330/ https://ncbi.nlm.nih.gov/pubmed/24865334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12772 |
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