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Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles

The blockbuster chemotherapy drug paclitaxel is widely presumed to cause cell death in tumors as a consequence of mitotic arrest, as it does at concentrations routinely used in cell culture. However, we determine here that paclitaxel levels in primary breast tumors are well below those required to e...

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Detalhes bibliográficos
Main Authors: Zasadil, Lauren M., Andersen, Kristen A., Yeum, Dabin, Rocque, Gabrielle B., Wilke, Lee G., Tevaarwerk, Amye J., Raines, Ronald T., Burkard, Mark E., Weaver, Beth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176609/
https://ncbi.nlm.nih.gov/pubmed/24670687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007965
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