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Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles
The blockbuster chemotherapy drug paclitaxel is widely presumed to cause cell death in tumors as a consequence of mitotic arrest, as it does at concentrations routinely used in cell culture. However, we determine here that paclitaxel levels in primary breast tumors are well below those required to e...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176609/ https://ncbi.nlm.nih.gov/pubmed/24670687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007965 |
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