Validating cancer drug targets through chemical genetics

por Burkard, Mark E., Jallepalli, Prasad V.
Publicado em 2010

High Mitotic Activity of Polo-like Kinase 1 Is Required for Chromosome Segregation and Genomic Integrity in Human Epithelial Cells

por Lera, Robert F., Burkard, Mark E.
Publicado em 2012

The Final Link: Tapping the Power of Chemical Genetics to Connect the Molecular and Biologic Functions of Mitotic Protein Kinases

por Lera, Robert F., Burkard, Mark E.
Publicado em 2012

Tuning chromosomal instability to optimize tumor fitness

por Burkard, Mark E., Weaver, Beth A.
Publicado no Cancer Discov (2017)

Synchronous bilateral breast cancer in a patient with Nager syndrome

por Denu, Ryan A., Burkard, Mark E.
Publicado no Clin Breast Cancer (2017)

Analysis of the “centrosome-ome” identifies MCPH1 deletion as a cause of centrosome amplification in human cancer

por Denu, Ryan A., Burkard, Mark E.
Publicado no Sci Rep (2020)

Enabling and disabling Polo-like kinase 1 inhibition through chemical genetics

por Burkard, Mark E., Santamaria, Anna, Jallepalli, Prasad V.
Publicado em 2012

Using Cancer Genomics to Guide Clinical Decisions

por Burkard, Mark E., Deming, Dustin A., Lauring, Josh
Publicado no Cancer (2017)

Update on Adjuvant Chemotherapy for Early Breast Cancer

por Rampurwala, Murtuza M, Rocque, Gabrielle B, Burkard, Mark E
Publicado em 2014

Photosensitive lichenoid skin reaction to capecitabine

por Shah, Rena A., Bennett, Daniel D., Burkard, Mark E.
Publicado no BMC Cancer (2017)

Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis

por Kim, Hyunjung, Guo, Feng, Brahma, Sarang, Xing, Yongna, Burkard, Mark E
Publicado no Cell Cycle (2014)

The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation

por Lasek, Amber L., McPherson, Brittany M., Trueman, Natalie G., Burkard, Mark E.
Publicado no PLoS One (2016)

Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis

por Kim, Hyunjung, Johnson, James M., Lera, Robert F., Brahma, Sarang, Burkard, Mark E.
Publicado no PLoS Genet (2017)

Centrosome amplification in cancer disrupts autophagy and sensitizes to autophagy inhibition

por Denu, Ryan A., Kaur, Gulpreet, Sass, Madilyn M, Lakkaraju, Aparna, Burkard, Mark E.
Publicado no Mol Cancer Res (2019)

CHARTS: a web application for characterizing and comparing tumor subpopulations in publicly available single-cell RNA-seq data sets

por Bernstein, Matthew N., Ni, Zijian, Collins, Michael, Burkard, Mark E., Kendziorski, Christina, Stewart, Ron
Publicado no BMC Bioinformatics (2021)

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

por Denu, Ryan A., Zasadil, Lauren M., Kanugh, Craig, Laffin, Jennifer, Weaver, Beth A., Burkard, Mark E.
Publicado no BMC Cancer (2016)

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

por Denu, Ryan A., Shabbir, Maria, Nihal, Minakshi, Singh, Chandra K., Longley, B. Jack, Burkard, Mark E., Ahmad, Nihal
Publicado no Mol Cancer Res (2018)

A physician-scientist preceptorship in clinical and translational research enhances training and mentorship

por Stefely, Jonathan A., Theisen, Erin, Hanewall, Chelsea, Scholl, Linda, Burkard, Mark E., Huttenlocher, Anna, Yu, John-Paul J.
Publicado no BMC Med Educ (2019)

Plk1 protects kinetochore–centromere architecture against microtubule pulling forces

por Lera, Robert F, Norman, Roshan X, Dumont, Marie, Dennee, Alexandra, Martin‐Koob, Joanne, Fachinetti, Daniele, Burkard, Mark E
Publicado no EMBO Rep (2019)

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells

por Burkard, Mark E., Randall, Catherine L., Larochelle, Stéphane, Zhang, Chao, Shokat, Kevan M., Fisher, Robert P., Jallepalli, Prasad V.
Publicado em 2007