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Enabling and disabling Polo-like kinase 1 inhibition through chemical genetics
Polo-like kinase 1 (Plk1) is a core regulator of cell division and an emerging target for cancer therapy. Pharmacologic inhibitors of Plk1 exist but affect other kinases complicating their in vivo validation. To address this, we examined effects of two structurally unrelated Plk1 inhibitors (BI-2536...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376236/ https://ncbi.nlm.nih.gov/pubmed/22422077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200551p |
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