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Plk1 protects kinetochore–centromere architecture against microtubule pulling forces
During mitosis, sister chromatids attach to microtubules which generate ~ 700 pN pulling force focused on the centromere. We report that chromatin‐localized signals generated by Polo‐like kinase 1 (Plk1) maintain the integrity of the kinetochore and centromere against this force. Without sufficient...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776907/ https://ncbi.nlm.nih.gov/pubmed/31468671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948711 |
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