High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation

Aneuploidy, an abnormal chromosome number that deviates from a multiple of the haploid, has been recognized as a common feature of cancers for >100 yr. Previously, we showed that the rate of chromosome missegregation/chromosomal instability (CIN) determines the effect of aneuploidy on tumors; whe...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Zasadil, Lauren M., Britigan, Eric M. C., Ryan, Sean D., Kaur, Charanjeet, Guckenberger, David J., Beebe, David J., Moser, Amy R., Weaver, Beth A.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2016
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Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927272/
https://ncbi.nlm.nih.gov/pubmed/27146113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0747
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