Persistence of Cisplatin-Induced Mutagenicity in Hematopoietic Stem Cells: Implications for Secondary Cancer Risk Following Chemotherapy

Cisplatin is a cytostatic agent used in the treatment of many types of cancer, but its use is associated with increased incidences of secondary leukemia. We evaluated cisplatin's in vivo genotoxic potential by analyzing peripheral blood for Pig-a mutant phenotype erythrocytes and for chromosoma...

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Hauptverfasser: Dertinger, Stephen D., Avlasevich, Svetlana L., Torous, Dorothea K., Bemis, Jeffrey C., Phonethepswath, Souk, Labash, Carson, Carlson, Kristine, Mereness, Jared, Cottom, John, Palis, James, MacGregor, James T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Genetic Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176048/
https://ncbi.nlm.nih.gov/pubmed/24798381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu078
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