Integration of Mutation and Chromosomal Damage Endpoints into 28-Day Repeat Dose Toxicology Studies

Two endpoints of genetic toxicity, mutation at the X-linked Pig-a gene and chromosomal damage in the form of micronucleated reticulocytes (MN-RETs), were evaluated in blood samples obtained from 28-day repeat-dosing studies typical of those employed in toxicity evaluations. Male Wistar Han rats were...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Dertinger, Stephen D., Phonethepswath, Souk, Franklin, Dean, Weller, Pamela, Torous, Dorothea K., Bryce, Steven M., Avlasevich, Svetlana, Bemis, Jeffrey C., Hyrien, Ollivier, Palis, James, MacGregor, James T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2010
Aiheet:
Genetic Toxicology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871757/
https://ncbi.nlm.nih.gov/pubmed/20202993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq070
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