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Identification of Key Residues Determining Isomerohydrolase Activity of Human RPE65

RPE65 is the retinoid isomerohydrolase that converts all-trans-retinyl ester to 11-cis-retinol, a key reaction in the retinoid visual cycle. We have previously reported that cone-dominant chicken RPE65 (cRPE65) shares 90% sequence identity with human RPE65 (hRPE65) but exhibits substantially higher...

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Bibliographic Details
Main Authors: Takahashi, Yusuke, Moiseyev, Gennadiy, Ma, Jian-xing
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175317/
https://ncbi.nlm.nih.gov/pubmed/25112876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558619
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