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Identification of Key Residues Determining Isomerohydrolase Activity of Human RPE65
RPE65 is the retinoid isomerohydrolase that converts all-trans-retinyl ester to 11-cis-retinol, a key reaction in the retinoid visual cycle. We have previously reported that cone-dominant chicken RPE65 (cRPE65) shares 90% sequence identity with human RPE65 (hRPE65) but exhibits substantially higher...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175317/ https://ncbi.nlm.nih.gov/pubmed/25112876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558619 |
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