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Purified RPE65 shows isomerohydrolase activity after re-association with a phospholipid membrane

Generation of 11-cis retinol from all-trans retinyl ester in the retinal pigment epithelium is a critical step in the visual cycle and is essential for perception of light. Recent studies from cell culture models suggest that protein RPE65 is the retinoid isomerohydrolase catalyzing the reaction. Ho...

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Bibliographic Details
Main Authors: Nikolaeva, Olga, Takahashi, Yusuke, Moiseyev, Gennadiy, Ma, Jian-xing
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777724/
https://ncbi.nlm.nih.gov/pubmed/19490105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07021.x
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