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Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts. Here, we an...

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Библиографические подробности
Главные авторы: LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174579/
https://ncbi.nlm.nih.gov/pubmed/25255098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02950
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