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Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila

The Drosophila glucoside xylosyltransferase Shams xylosylates Notch and inhibits Notch signaling in specific contexts including wing vein development. However, the molecular mechanisms underlying context-specificity of the shams phenotype is not known. Considering the role of Delta-Notch signaling i...

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Vydáno v:PLoS Genet
Hlavní autoři: Lee, Tom V., Pandey, Ashutosh, Jafar-Nejad, Hamed
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402982/
https://ncbi.nlm.nih.gov/pubmed/28394891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006723
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